Understanding the ‘eating just one potato chip is impossible’ gene

A research group has revealed that a transcription cofactor gene called CREB-Regulated Transcription Coactivator 1 (CRTC1) mediates the obesity-suppressing effects of melanocortin-4 receptor (MC4R) by regulating appetite for fats and oils, high-fat diet metabolism, and blood sugar. They found that there was no difference in weight gain between mice without CRTC1 in their MC4R-expressing neurons and control mice when they were reared on a standard diet. However, when given a high-fat diet, the CRTC1-deficient mice overate, becoming significantly obese and developing diabetes.

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