Meet Squeegee: A new contamination detection tool for low microbial biomass microbiomes

One of the major challenges in microbiome science has been distinguishing what is a potential environmental contaminant from a true, bona fide microbiome signal in low biomass studies — studies that contain little microbial DNA like breastmilk, placenta or amniotic fluid. For instance, it can be challenging to differentiate between the DNA of a microbe in a sample from remnant contaminant DNA from a sampling kit or extraction kit or the environment.

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