Chemotherapy could increase disease susceptibility in future generations

A common chemotherapy drug could carry a toxic inheritance for children and grandchildren of adolescent cancer survivors, new research indicates. The study found that male rats who received the drug ifosfamide during adolescence had offspring and grand-offspring with increased incidence of disease. While other research has shown that cancer treatments can increase patients’ chance of developing disease later in life, this is one of the first-known studies showing that susceptibility can be passed down to a third generation of unexposed offspring.

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