Molecular chaperones caught in flagrante

For an adequate immune response, it is essential that T lymphocytes recognize infected or degenerated cells. They do so by means of antigenic peptides, which these cells present with the help of specialized surface molecules (MHC I molecules). Using X-ray structure analysis, a research team has now been able to show how the MHC I molecules are loaded with peptides and how suitable peptides are selected for this purpose.

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